Thank you! Alexey , 

jot server name jot.domain.com

1，messenger  settings change to:

https://jot.domain.com:5000

2, the cert and key file path:

/home/domain/ssl.cert

/home/domain/ssl.key

jot-server config:

{

    "port":5000,

    "mode":"",

    "log":"log.log",

    "domains":["*"],

    "transformer":"sockjs",

    "root":"/home/domain",

    "cert":"ssl.cert", 

    "key":"ssl.key",

    "OFFLINE":0,

    "ONLINE":1,        

    "AWAY":2

}

3, forever list show there running:

info:    Forever processes running

data:     uid  command   script forever pid  id logfile    uptime                   

data:    [0] X2v_ /usr/bin/node app.js 2063    2204    /home/domian/.forever/X2v_.log 0:0:5:10.048999999999978 

4, telnet [jot-server external ip] 5000

Connected to 55.*.*.100.

Escape character is '^]'

but on the internet, it's cant connected. 

I check everywhere, closed system firewall,   it's still didn't working.